A naturally occurring terpene alcohol found in German chamomile, the Brazilian candeia tree, and produced synthetically. Valued for its anti-inflammatory and skin-calming properties, bisabolol appears in 4,701 products in our database. The CIR Expert Panel concluded it is safe as used in cosmetics, though it is classified as a weak skin sensitizer (GHS H317) — overall well-tolerated but not zero-risk.
A skin-conditioning agent commonly sourced from chamomile, the Brazilian candeia tree, or produced synthetically. It is used in cosmetic formulations for its anti-inflammatory properties and may help soothe irritated skin and reduce the appearance of redness. Bisabolol also functions as a fragrance ingredient. While it has a generally favourable safety profile, it is classified as a weak skin sensitizer (GHS H317) — well-tolerated by most users, but individuals with fragrance sensitivities should exercise caution.
(−)-α-Bisabolol (CAS No. 515-69-5) is an unsaturated monocyclic terpene alcohol with the molecular formula C15H26O and a molecular weight of 222.37 g/mol. It is a major component of chamomilla recutita (matricaria) flower oil, which may contain up to 41.45% (−)-α-bisabolol. While natural bisabolol is extracted from chamomile or the Brazilian candeia tree (Vanillosmopsis erythropappa), it can also be produced synthetically. Bisabolol exists in both α- and β-configurations with four stereoisomers; the (−)-α-bisabolol form is the one most commonly used in cosmetics.
According to CIR data, bisabolol was used in 184 cosmetic formulations at typical concentrations of 0.1–0.2%. By the 2015 re-review, the frequency of use had increased substantially while concentrations remained unchanged. The RIFM safety assessment (2020) documented industry use ranging from 0.001% in lipsticks to 1% in underarm deodorants. Notably, bisabolol has been shown to act as a skin penetration enhancer, with synergistic effects when combined with propylene glycol — the CIR Panel specifically cautioned formulators about increased absorption of other ingredients in formulations containing bisabolol.
Bisabolol's most studied property is its anti-inflammatory activity. It is commonly used in formulations intended to calm irritated skin and may help reduce the appearance of redness from environmental stressors. Frequently found in after-sun and post-procedure products.
Acts as a gentle skin-conditioning agent that calms sensitive and reactive skin. Particularly beneficial for those with rosacea-prone or easily irritated skin, helping to restore comfort and reduce visible irritation.
Clinical studies show bisabolol enhances the absorption of other active ingredients through the skin. This makes it valuable in formulations where it can boost the efficacy of companion ingredients like vitamins and peptides.
CIR concluded "safe as used" and RIFM confirmed a NESIL of 5,500 μg/cm², placing bisabolol as a weak sensitizer with a high threshold. Negative for sensitization at 0.1% in clinical testing and negative for phototoxicity. However, GHS H317 classification means some individuals — particularly those with fragrance allergies — may experience skin reactions.
Generally suitable for: Most skin types — sensitive, dry, combination, and normal. Commonly used in formulations for irritation-prone skin. Individuals with fragrance allergies should patch-test first. Individual tolerance may vary.
The CIR Expert Panel (1997, reaffirmed 2015) concluded that bisabolol is safe as used in cosmetic formulations. RIFM (2020) confirmed MOE > 100 for all systemic endpoints. EU approved with no restrictions.
Although bisabolol has a high sensitization threshold (NESIL 5,500 μg/cm²), it carries a GHS H317 classification for skin sensitization. Individuals with known fragrance allergies or very sensitive skin should patch-test first.
Bisabolol is a demonstrated skin penetration enhancer, particularly synergistic with propylene glycol. While this can boost the efficacy of beneficial active ingredients, formulators should be aware it may also increase absorption of potentially irritating ingredients.
The CIR Panel specifically noted that bisabolol is used in baby products and cautioned about the possibility of increased absorption of other ingredients whose safety is based on their lack of dermal absorption.
The CIR 1997 report found bisabolol was not teratogenic in an oral dose study using rats. The RIFM 2020 assessment confirmed a developmental NOAEL of 980 mg/kg/day, with a calculated MOE > 100. However, RIFM also noted that reproductive toxicity data are insufficient — the reproductive endpoint was evaluated using the Threshold of Toxicological Concern (TTC) for a Cramer Class I material rather than direct reproductive studies. This means bisabolol has not been conclusively established as safe during pregnancy; rather, current exposure levels are considered below the threshold of concern. These findings are from animal studies only; no human clinical trials exist. Always consult your healthcare provider.
Start with clean skin. Apply your cleanser and pat dry gently.
Apply your bisabolol-containing serum or treatment. Bisabolol is most commonly found at 0.1–0.5% in serums and creams. Its penetration-enhancing properties help other active ingredients absorb better.
Follow with your moisturizer to lock in the benefits. Bisabolol pairs well with ceramides and hyaluronic acid for comprehensive soothing and hydration.
Finish with SPF in the morning. While bisabolol is not photosensitizing, sun protection is always recommended as part of a complete routine.
Best for targeted soothing. Lightweight formulas with 0.1–0.5% bisabolol absorb quickly and layer easily. Ideal for sensitive or combination skin.
Best for dry or irritated skin. Richer formulations that combine bisabolol's soothing action with occlusives for lasting comfort and barrier support.
Best for after-sun or post-procedure care. As a terpene alcohol, bisabolol blends naturally into oil-based products. Great for targeted application on irritated areas.
Both have anti-inflammatory properties. Niacinamide strengthens the barrier while bisabolol calms irritation — complementary mechanisms with no conflict.
HA provides deep hydration while bisabolol soothes and conditions. A great combination for sensitive, dehydrated skin.
Occlusives that lock in the benefits while bisabolol soothes underneath. Ideal for sensitive skin barrier repair routines.
Double soothing power. Both are botanical calming ingredients. Together, they provide comprehensive anti-inflammatory support for reactive skin.
Bisabolol enhances penetration of other ingredients. While this can boost efficacy, it may also increase irritation potential of strong actives. Introduce gradually.
CIR noted synergistic penetration enhancement between bisabolol and propylene glycol. Be mindful of this interaction, especially in formulations for babies or individuals with compromised skin barriers.
Found in 4,701 products in our database. Here are some well-known options:
Scan your skincare products and get instant ingredient analysis with SkinSenseDiary.
Download the App