A well-established skin-conditioning ingredient listed in the U.S. FDA OTC Skin Protectant Monograph. Allantoin is valued for its soothing, moisturising, and mild keratin-softening properties, and is found in thousands of cosmetic products across all categories.
Allantoin (INCI: Allantoin, CAS 97-59-6) is a diureide of glyoxylic acid, also known as (2,5-dioxo-4-imidazolidinyl)urea. It is found naturally in comfrey root (Symphytum officinale), sugar beet, wheat sprouts, and chamomile. Most cosmetic-grade Allantoin is produced synthetically via oxidation of uric acid, yielding a high-purity white crystalline powder. The CIR Expert Panel (2010) concluded that Allantoin and its related complexes are safe as used in cosmetics.
Allantoin has a long regulatory history. It is listed in the U.S. FDA OTC Skin Protectant Monograph as a recognised active ingredient at concentrations of 0.5% to 2% for minor cuts, burns, and skin irritation. In the EU, it is registered in CosIng (#31411) with approved functions including skin conditioning and soothing, and is not listed in Annex II (prohibited) or Annex III (restricted), meaning it has no specific concentration limits in cosmetic products. It has been used in pharmaceutical and cosmetic formulations for over 70 years.
Allantoin functions through multiple mechanisms: it may support keratinocyte renewal and the skin's natural repair cycle, it has mild keratin-softening (keratolytic-like) properties that help smooth rough skin by facilitating the shedding of dead surface cells, and it acts as a humectant contributing to skin hydration. CIR industry survey data indicate Allantoin is used across a wide range of product categories — from moisturisers and cleansers to sunscreens and baby care products — at typical concentrations of 0.1% to 2%.
Allantoin helps calm irritated and inflamed skin. Its soothing properties make it a staple in after-sun products, post-procedure care, and formulations for reactive skin. The FDA recognises it as a skin protectant that temporarily protects minor skin irritation.
As a humectant, Allantoin helps attract and retain moisture in the stratum corneum, contributing to softer and smoother skin texture. It is often combined with other moisturising agents in formulations for dry skin.
Allantoin has mild keratin-softening properties (keratolytic-like effect) — it supports the gentle loosening of dead skin cells from the surface, helping to smooth rough or flaky patches. Compared to dedicated exfoliants such as AHAs or BHAs, this effect is very mild, making it suitable for sensitive skin.
Allantoin may support keratinocyte renewal and the skin's natural repair process (limited evidence). This is one of the reasons it is commonly included in wound care and post-procedure formulations, though the degree of effect depends on concentration and formulation.
Generally suitable for: Most skin types, including sensitive, dry, irritated, and acne-prone skin. Allantoin is one of the gentlest active ingredients available and is widely used in baby care products. Individual tolerance may vary depending on the overall formulation.
The CIR Expert Panel (2010) reviewed all available safety data and concluded that Allantoin and its related complexes are safe as used in cosmetics. Allantoin is listed in the U.S. FDA OTC Skin Protectant Monograph as a recognised active ingredient (0.5–2%). Not listed in EU Annex II (prohibited) or Annex III (restricted).
Allantoin is historically derived from comfrey root (Symphytum officinale), but comfrey also contains pyrrolizidine alkaloids (PAs) which are toxic to the liver. Cosmetic-grade Allantoin is produced synthetically and does not contain PAs. If you encounter "comfrey extract" products, note that these are distinct from purified Allantoin.
While some literature describes Allantoin as supporting keratinocyte renewal, the evidence is limited. It should be understood as supporting the skin's natural renewal cycle — it is not a pharmacologically active growth factor. The degree of effect depends on concentration and the overall formulation.
Allantoin is generally considered a low-risk topical ingredient during pregnancy and nursing. The CIR 2010 report noted oral developmental toxicity studies in rats and rabbits at doses well above cosmetic exposure levels showed no teratogenic effects. As a topical cosmetic ingredient, systemic absorption is expected to be minimal. However, no dedicated clinical trials have specifically studied pregnant human populations. Consult your healthcare provider for personal advice.
Two gentle soothing agents that complement each other. Panthenol adds moisturising depth while Allantoin contributes skin-protecting properties. A classic combination in sensitive skin formulations.
Allantoin soothes and supports skin renewal while ceramides rebuild the lipid barrier. Together they provide comprehensive repair for dry or compromised skin.
Niacinamide strengthens the skin barrier and helps with uneven tone; Allantoin soothes and conditions. No conflicts — they work well in the same formulation.
Allantoin's soothing and protective properties can help offset the dryness and irritation that retinol may cause. Using an Allantoin product alongside retinol is a common strategy to improve tolerability.
Allantoin's stability may be affected in very low pH environments (formulation-dependent). If using strong acid exfoliants, consider applying them at separate times of day as a precaution.
Do not confuse purified Allantoin with whole comfrey extract. Comfrey contains pyrrolizidine alkaloids that are hepatotoxic. Synthetic Allantoin is PA-free and safe for cosmetic use.
Found in thousands of products across our database. Allantoin is one of the most widely used soothing ingredients in skincare. Here are some well-known options (ingredient lists verified via INCI):
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