数据来源：EU CosIng (#35839)，CIR 泛醇、泛酸及其衍生物安全评估（2022），和 SkinSenseDiary 内部评估。最后更新：2026 年 4 月。
成分概览
Also Known As
Pro-Vitamin B5, D-Panthenol, Dexpanthenol, 泛醇
CosIng Functions
Humectant, Skin Conditioning
Source
Synthetic (identical to natural Vitamin B5 precursor)
Regulation
No restrictions
什么是泛醇？
该保湿成分作为吸湿剂能够为肌肤补充水分，并有助改善角质层含水量与屏障功能。由于其舒缓特性和改善肌肤纹理及柔软度的能力，它常被添加到护肤配方中。这种成分具有出色的安全特性，刺激风险极低，适合所有肤质，特别是敏感肌肤。
泛醇（INCI：泛醇，CAS 81-13-0）是泛酸（维生素 B5）的醇类似物。一旦被肌肤吸收，泛醇就会被酶转化为泛酸，泛酸是辅酶 A 的关键成分 — 对许多代谢过程至关重要，包括肌肤细胞中的脂肪酸合成和能量生成。这种转化就是使泛醇成为「原维生素」的原因。它以 D-泛醇（生物活性形式）和 DL-泛醇（外消旋混合物）的形式存在，两者都广泛用于化妆品中。
CIR 专家委员会在 2022 年评估了泛醇、泛酸及其五种衍生物，得出结论认为它们在目前的化妆品使用方式和浓度下是安全的。根据 FDA VCRP 数据，泛醇在留在型产品中的使用浓度高达 5.3%，在冲洗型产品中高达 5%。CIR 发现全身毒性风险低，但指出这些成分可能含有残留胺作为杂质，这是配方层面的考量，制造商需确保适当处理以防止 N-亚硝基化合物的形成。
功效 — 4 大核心作用
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保湿补水
泛醇是一种强效吸湿剂，能吸收水分并结合到肌肤中，增加角质层的水分含量。研究表明它能提供即时和持久的保湿效果，减少干燥和脱皮现象。
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舒缓与修复
研究支持泛醇在促进肌肤修复中的作用。体外研究表明它可能支持细胞增殖与迁移。这使其成为愈合产品和术后护肤中的常见成分。泛醇的舒缓特性对受损或敏感肌肤特别有益。
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抗炎舒缓
泛醇可舒缓受刺激、发红的敏感肌肤。它减少由紫外线暴露、环保压力和刺激性护肤活性成分引起的炎症。这使其成为去角质或日晒后的理想恢复成分。
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屏障强化
通过增强肌肤的脂质合成，泛醇帮助加强肌肤屏障。更强的屏障意味着更少的经表皮水分流失（TEWL），对刺激物的更好保护，以及整体更有韧性的肌肤。
适合人群：所有肤质 — 特别是敏感、干性、受刺激的肌肤以及术后肌肤。也适合护发调理。
安全评级：1/10（低危害）
安全使用验证
CIR 专家委员会（2022）得出结论，泛醇及其衍生物在目前的化妆品使用方式和浓度下是安全的。EU 批准，无限制。一种耐受性好、安全记录出众的原维生素。
Evidence
CIR Assessment
✓ Safe as Used (2022)
CIR 评估了泛醇、泛酸及其 5 种衍生物。在留在型产品中的报告浓度高达 5.3% 时是安全的。全身毒性风险低。具有吸湿剂、肌肤调理和护发调理功能。
EU Regulation
✓ No Restrictions
Not listed in Annex II (prohibited), III (restricted), or IV. Registered in CosIng as #35839. EU-wide unrestricted use in cosmetics.
Allergen & Sensitivity
✓ Overall Well-Tolerated
No allergen tags in our database. No GHS hazard codes. CIR 数据中包含接触性皮炎的个案报告，但这些病例罕见。整体耐受性佳，致敏风险低。适合敏感肌肤使用。
CosIng
Approved Functions
吸湿剂 · 肌肤调理 · 溶剂。EU CosIng 批准的功能。泛醇将水分吸入肌肤并改善质地和柔软度，同时也用作护发调理剂和溶剂。
Things to Know
CIR 小组指出泛醇可能含有残留胺作为杂质，这是配方层面的考量。信誉良好的制造商确保适当的配方处理以防止风险。
泛醇的有效浓度范围：行业报告显示产品中使用浓度从 1% 到 5.3%。这些是市场观察到的使用水平，而非功效推荐。实际益处因产品类型和肤质而异。
Both D-Panthenol and DL-Panthenol are used in cosmetics. D-Panthenol is the biologically active form and is generally preferred for skin benefits, while DL-Panthenol works well for hair conditioning.
Pregnancy & Nursing
Panthenol (Pro-Vitamin B5) is a water-soluble vitamin precursor naturally found in many foods including eggs, meat, and whole grains. The CIR 2022 assessment found low systemic toxicity potential. However, safety during pregnancy and nursing should be assessed on an individual basis rather than relying solely on market prevalence. The presence in baby skincare products reflects market practices, not definitive pregnancy safety evidence. Always consult your healthcare provider for personal advice.
Safety data compiled from CIR Safety Assessment of Panthenol, Pantothenic Acid, and Derivatives (2022), EU CosIng Database, and SkinSenseDiary internal analysis. This is for educational purposes only and does not constitute medical advice. Last updated: April 2026.
搭配指南
完美搭配
透明质酸
两种相互协作的吸湿剂 — HA 和泛醇都有助增加肌肤含水量。透明质酸提供强劲的补水，泛醇则舒缓并改善肌肤条理。一起它们提供全面的保湿效果。
烟酰胺（维生素 B3）
泛醇（B5）和烟酰胺（B3）是经典的 B 族维生素组合。烟酰胺强化屏障并控制油脂，泛醇补充水分并舒缓。它们完美互补。
神经酰胺
泛醇促进肌肤脂质合成，支持神经酰胺直接提供的屏障修复。一起它们加快干性、受损肌肤的屏障恢复。
视黄醇
泛醇的舒缓和保湿特性有助于抵消视黄醇的干燥和刺激。先涂抹视黄醇，然后叠加泛醇以在视黄醇疗法期间舒缓和保护肌肤。
谨慎搭配
强果酸焕肤（>15% AHA）
非常高浓度的果酸焕肤可能会暂时破坏肌肤屏障。将泛醇用作焕肤后的恢复护理，而不是在焕肤的同时叠加使用。
含有胺类防腐剂的产品
根据 CIR 的警告，泛醇不应在可能形成 N-亚硝基化合物的配方中使用。这是配方层面的考量，由制造商在产品开发阶段处理，不是消费者叠加使用的问题。
热门产品
精选含有泛醇的产品。数据库产品数：11,581
La Roche-Posay
Cicaplast Baume B5+
Healing Balm
CosRX
Balancium Comfort Ceramide Cream
Moisturizer
Drunk Elephant
Protini Polypeptide Cream
Moisturizer
The Ordinary
Multi-Peptide + HA Serum
Serum
Paula's Choice
Skin Recovery Replenishing Moisturizer
Moisturizer
Avène
Cicalfate+ Restorative Protective Cream
Healing Cream
常见问题
Is Panthenol safe for sensitive skin?
Yes. Panthenol has a SkinSenseDiary safety rating of 1/10 (Low Hazard). The CIR 专家委员会（2022） concluded Panthenol and its derivatives are safe as used in cosmetics. It is the provitamin form of Vitamin B5, naturally present in many foods and well-tolerated by skin. No known allergen flags or GHS hazard codes. In fact, Panthenol is widely used in products specifically designed for sensitive and irritated skin.
Can I use Panthenol every day?
Yes. Panthenol is safe for daily use, morning and night. The CIR assessment (2022) found it has low potential for systemic toxicity and is well-tolerated at concentrations up to 5.3% in leave-on products. As a provitamin that converts to Vitamin B5 in the skin, regular use supports ongoing hydration and barrier maintenance.
Can I use Panthenol with Retinol?
Yes, and it's an excellent pairing. Panthenol's soothing and hydrating properties help counteract the dryness, irritation, and peeling that retinol can cause. Apply retinol first, then layer a Panthenol-containing moisturizer or serum to calm and protect the skin while the retinol works.
Is Panthenol safe during pregnancy?
Panthenol (Pro-Vitamin B5) is a water-soluble vitamin precursor naturally found in many foods. The CIR 2022 assessment found low systemic toxicity potential. It is widely regarded as safe during pregnancy and nursing. Panthenol is commonly found in baby skincare products, further supporting its gentle safety profile. Always consult your healthcare provider for personal advice.
What is the difference between Panthenol and Pantothenic Acid?
Panthenol is the provitamin (alcohol) form of Vitamin B5, while Pantothenic Acid is the active vitamin itself. When applied topically, Panthenol is absorbed into the skin and converted to Pantothenic Acid by enzymes. Panthenol is preferred in cosmetics because it penetrates skin more readily than Pantothenic Acid and is more stable in formulations.
What concentration of Panthenol is effective?
Panthenol is effective at concentrations as low as 1%, though most skincare products use 2–5%. The CIR reports leave-on products containing up to 5.3% Panthenol. At 5%, studies show significant improvements in skin hydration, barrier function, and wound healing. Higher concentrations are safe but may not provide proportionally greater benefits.
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